Jonathan Choi

Ph.D. candidate in Chemical Engineering

Education:

B.S. in Chemical Engineering, Stanford University, 2005
M.S. in Chemical Engineering, Stanford University, 2006

Research Overview :

My research seeks to understand the behavior of nanoparticles in vivo. With the aid of immuno-histochemistry, microscopy, and bioconjugate chemistry, it investigates the effects of various physicochemical parameters (such as size, surface charge, ligand density, ligand type, and etc.) on the in vivo distribution and pharmacokinetics of nanoparticle-based modeling agents in the organ, tissue, and cellular levels in animal models. Results from such studies, when benchmarked against systemic administration of actual nanoparticles carrying the therapeutic payload, can provide insight to the mechanism governing the effective delivery of nanoparticles with elevated targeting capabilities.

Publications:

Davis, M.E., Zuckerman, J.E., Choi, C.H.J., Seligson, D., Tolcher, A., Alabi, C.A., Yen, Y., Heidel, J.D., Ribas, A. Evidence of RNAi in humans from systemically adminstered siRNA via targeted nanoparticles. Nature, 464, 7291, 1067-1070 (2010).

Choi, C.H.J., Alabi, C.A., Webster, P., Davis, M.E. Mechanism of active targeting in solid tumors with transferrin-containing gold nanoparticles. Proc. Nat. Acad. Sci. USA, 107, 3, 1235-1240 (2010).

Schluep, T., Hwang, J., Hildebrandt, I., Czernin, J., Choi, C.H.J., Alabi, C.A., Mack, B.C., Davis, M.E. Pharmacokinetics and tumor dynamics of the manoparticle IT-101 from PET imaging and tumor histological measurements. Proc. Nat. Acad. Sci. USA, 106, 27, 11394-11399 (2009).