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Membrane Deformation

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Cellulose Hydrolysis

We are studying the mechanism by which the cellulase enzyme has evolved to overcome and hydrolyze the recalcitrant nature of cellulosic biomass. Cellulase consists of two independent domains coupled by a peptide linker. How these two domains work together to achieve the desired hydrolysis is a key question of considerable controversy. To better understand the role of the linker, we have developed a mechanochemical model, whereby the free energy gain from the cellulose hydrolysis provides the driving force for the motion of the CD, which is then coupled to the motion of the CBM through the linker.
Funding: NIH training grant

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